{"id":87765,"date":"2024-10-07T18:38:23","date_gmt":"2024-10-07T23:38:23","guid":{"rendered":"https:\/\/thecitizenfortheworld.com\/?p=87765"},"modified":"2024-10-07T18:38:23","modified_gmt":"2024-10-07T23:38:23","slug":"que-son-los-microarn-por-los-que-victor-ambros-y-gary-ruvkun-ganaron-el-premio-nobel-de-medicina","status":"publish","type":"post","link":"https:\/\/thecitizenfortheworld.com\/?p=87765","title":{"rendered":"Qu\u00e9 son los microARN por los que Victor Ambros y Gary Ruvkun ganaron el Premio Nobel de Medicina"},"content":{"rendered":"
\n
Victor Ambros y Gary Ruvkun ganaron este lunes el Premio Nobel de Medicina.<\/b><\/span><\/div>\n<\/figure>\n
\n

Los dos cient\u00edficos estadounidenses\u00a0descubrieron los microARN<\/b>, una nueva clase de diminutas mol\u00e9culas de ARN que desempe\u00f1an un papel crucial en la regulaci\u00f3n de los genes.<\/p>\n<\/div>\n

\n

Su revolucionario descubrimiento en el peque\u00f1o gusano\u00a0C. elegans<\/i>\u00a0revel\u00f3 un principio completamente nuevo de regulaci\u00f3n gen\u00e9tica, que result\u00f3 ser esencial para los organismos pluricelulares, incluido el ser humano.<\/p>\n<\/div>\n

\n

Durante d\u00e9cadas, la comunidad cient\u00edfica prest\u00f3 poca atenci\u00f3n a este descubrimiento. Seg\u00fan la Fundaci\u00f3n Nobel, se pensaba que este mecanismo era “una peculiaridad” de un gusano, algo “probablemente irrelevante para los humanos y otros animales m\u00e1s complejos”. Pero no.<\/p>\n<\/div>\n

<\/section>\n
\n

El trabajo de Ambros y Ruvkun ayud\u00f3 a explicar\u00a0c\u00f3mo funcionan nuestros genes dentro del cuerpo humano y c\u00f3mo eso da lugar al desarrollo de los distintos tejidos en nuestro organismo<\/b>.<\/p>\n<\/div>\n

\n

De hecho, “ahora se sabe que el genoma humano codifica m\u00e1s de 1.000 microARN”, explica la Fundaci\u00f3n Nobel.<\/p>\n<\/div>\n

\n

Los ganadores se repartir\u00e1n un premio de 11 millones de coronas suecas (aproximadamente US$1 mill\u00f3n).<\/p>\n<\/div>\n

\n

Particularidades gen\u00e9ticas<\/h2>\n<\/div>\n
\n

Todas las c\u00e9lulas del cuerpo humano contienen la misma informaci\u00f3n gen\u00e9tica en bruto, encerrada en nuestro ADN.<\/p>\n<\/div>\n

\n

Pero, a pesar de partir de la misma informaci\u00f3n gen\u00e9tica, las c\u00e9lulas del cuerpo humano son\u00a0muy diferentes en forma y funci\u00f3n.<\/b><\/p>\n<\/div>\n

\n

Los impulsos el\u00e9ctricos de las c\u00e9lulas nerviosas son distintos de los latidos r\u00edtmicos de las c\u00e9lulas card\u00edacas. La central metab\u00f3lica que es una c\u00e9lula hep\u00e1tica es distinta de una c\u00e9lula renal que filtra la urea de la sangre. La capacidad de detecci\u00f3n de la luz de las c\u00e9lulas de la retina es distinta de la de los gl\u00f3bulos blancos que producen anticuerpos para combatir las infecciones.<\/p>\n<\/div>\n

\n

Toda esta variedad puede surgir del mismo material de partida gracias a la\u00a0expresi\u00f3n gen\u00e9tica<\/b>.<\/p>\n<\/div>\n

\n

Los cient\u00edficos estadounidenses fueron los primeros en descubrir los microARN y c\u00f3mo estos ejercen un\u00a0control sobre la forma en que los genes se expresan<\/b>\u00a0de manera diferente en los distintos tejidos.<\/p>\n<\/div>\n

\n
\"Anuncio<\/p>\n

Fuente de la imagen, <\/span>Getty Images<\/span><\/p>\n<\/div>

Pie de foto, <\/span>Los ganadores compartir\u00e1n un premio de cerca de US$1 mill\u00f3n.<\/span><\/span><\/figcaption><\/figure>\n
\n

Sin la capacidad de controlar la expresi\u00f3n g\u00e9nica, cada c\u00e9lula de un organismo ser\u00eda id\u00e9ntica, por lo que los microARN ayudaron a posibilitar la\u00a0evoluci\u00f3n de formas de vida complejas.<\/b><\/p>\n<\/div>\n

\n

La regulaci\u00f3n an\u00f3mala de los microARN puede contribuir al c\u00e1ncer y a algunas enfermedades como la p\u00e9rdida de audici\u00f3n cong\u00e9nita y los trastornos \u00f3seos.<\/p>\n<\/div>\n

\n

Un ejemplo es el s\u00edndrome DICER1, que provoca c\u00e1ncer en diversos tejidos y est\u00e1 causado por mutaciones que afectan a los microARN.<\/p>\n<\/div>\n

\n

C\u00f3mo funciona<\/h2>\n<\/div>\n
\n

Ambros y Ruvkun investigaron sobre el gusano nematodo\u00a0C. elegans.<\/i><\/p>\n<\/div>\n

\n

“Vieron unos gusanos que parec\u00edan un poco raros y decidieron entender por qu\u00e9”<\/b>, cuenta Olle K\u00e4mpe, miembro del Comit\u00e9 Nobel.<\/p>\n<\/div>\n

\n

Experimentaron con una forma mutante del gusano que no desarrollaba algunos tipos de c\u00e9lulas.<\/p>\n<\/div>\n

\n

Y finalmente dieron con peque\u00f1os fragmentos de material gen\u00e9tico o microARN que eran esenciales para el desarrollo de los gusanos.<\/p>\n<\/div>\n

\n

As\u00ed es como funciona:<\/p>\n<\/div>\n

\n
    \n
  • Nuestro ADN contiene un gen o instrucci\u00f3n gen\u00e9tica.<\/li>\n
  • Nuestras c\u00e9lulas hacen una copia, llamada ARN mensajero o simplemente ARNm (lo recordar\u00e1s de las vacunas covid).<\/li>\n
  • Este ARN sale del n\u00facleo de la c\u00e9lula y ordena a las f\u00e1bricas de prote\u00ednas de la c\u00e9lula que empiecen a producir una prote\u00edna espec\u00edfica.<\/li>\n
  • Pero los microARN se interponen en el camino adhiri\u00e9ndose al ARN mensajero y detienen su funcionamiento.<\/li>\n
  • En esencia, el mircoARN ha impedido que el gen se exprese en la c\u00e9lula.<\/li>\n<\/ul>\n<\/div>\n
    \n

    Otros trabajos demostraron que no se trata de un proceso exclusivo de los gusanos, sino de\u00a0un componente esencial de la vida en la Tierra<\/b>.<\/p>\n<\/div>\n

    \n
    \"Cuerpo<\/p>\n

    Fuente de la imagen, <\/span>Getty Images<\/span><\/p>\n<\/div>\n<\/figure>\n

    \n

    “Su trabajo pionero sobre la regulaci\u00f3n gen\u00e9tica por microARN allan\u00f3 el camino a investigaciones sobre terapias novedosas para enfermedades devastadoras como la epilepsia<\/b>, pero tambi\u00e9n nos abrieron los ojos a la maravillosa maquinaria que controla estrechamente lo que ocurre en nuestras c\u00e9lulas”, dijo a la BBC Janosch Heller de la Universidad de la Ciudad de Dubl\u00edn.<\/p>\n<\/div>\n

    \n

    Los ganadores de los premios de Medicina y Fisiolog\u00eda son elegidos por la Asamblea Nobel del Instituto Karolinska de Suecia.<\/p>\n<\/div>\n

    \n

    El Premio Nobel de Fisiolog\u00eda o Medicina se ha concedido\u00a0115 veces a 227 galardonados entre 1901 y 2023<\/b>.<\/p>\n<\/div>\n

    \n

    El a\u00f1o pasado, el premio fue otorgado a Katalin Karik\u00f3 y Drew Weissman por la vacuna de la covid basada en ARN mensajero.<\/p>\n<\/div>\n

    <\/figure>\n
    \n

    Con informaci\u00f3n de BBC News Mundo.<\/i><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Victor Ambros y Gary Ruvkun ganaron este lunes el Premio Nobel de Medicina. Los dos cient\u00edficos estadounidenses\u00a0descubrieron los microARN, una nueva clase de diminutas mol\u00e9culas de ARN que desempe\u00f1an un papel crucial en la regulaci\u00f3n de los genes. Su revolucionario descubrimiento en el peque\u00f1o gusano\u00a0C. elegans\u00a0revel\u00f3 un principio completamente nuevo de regulaci\u00f3n gen\u00e9tica, que result\u00f3 […]<\/p>\n","protected":false},"author":1,"featured_media":87766,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_mi_skip_tracking":false},"categories":[6],"tags":[],"yoast_head":"\nQu\u00e9 son los microARN por los que Victor Ambros y Gary Ruvkun ganaron el Premio Nobel de Medicina - The citizen for the world<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/thecitizenfortheworld.com\/?p=87765\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Qu\u00e9 son los microARN por los que Victor Ambros y Gary Ruvkun ganaron el Premio Nobel de Medicina - The citizen for the world\" \/>\n<meta property=\"og:description\" content=\"Victor Ambros y Gary Ruvkun ganaron este lunes el Premio Nobel de Medicina. 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