{"id":84803,"date":"2024-03-26T08:57:18","date_gmt":"2024-03-26T13:57:18","guid":{"rendered":"https:\/\/thecitizenfortheworld.com\/?p=84803"},"modified":"2024-03-26T08:57:18","modified_gmt":"2024-03-26T13:57:18","slug":"avance-clave-en-el-tratamiento-del-alzheimer-la-reduccion-de-una-enzima-del-cerebro-puede-proteger-contra-la-enfermedad","status":"publish","type":"post","link":"https:\/\/thecitizenfortheworld.com\/?p=84803","title":{"rendered":"Avance clave en el tratamiento del Alzheimer: la reducci\u00f3n de una enzima del cerebro puede proteger contra la enfermedad"},"content":{"rendered":"<p>Un ensayo en ratones muestra que la reducci\u00f3n de la enzima PDE4B disminuye la inflamaci\u00f3n del cerebro, propia de este tipo de demencia<\/p>\n<p>Un grupo de investigadores de la Universidad de Leeds y la Universidad de Lancaster en el Reino Unido han identificado un nuevo objetivo potencial para el\u00a0<b>tratamiento\u00a0<\/b>de la enfermedad de\u00a0<b>Alzheimer<\/b>: la\u00a0<b>PDE4B<\/b>. La PDE4B es una enzima localizada dentro de las c\u00e9lulas cuya funci\u00f3n es descomponer una mol\u00e9cula conocida como AMP c\u00edclico, que regula una variedad de procesos celulares. Los resultados de la investigaci\u00f3n han sido publicados en la revista\u00a0<i>Neuropsychopharmacology.<\/i><\/p>\n<p>Los cient\u00edficos partieron de un estudio previo realizado por equipo australiano que logr\u00f3 identificar este gen como un factor de riesgo para desarrollar Alzheimer. A ra\u00edz de este hallazgo, los investigadores investigaron si la\u00a0<b>reducci\u00f3n de la actividad de esta hormona\u00a0<\/b>podr\u00eda ser una\u00a0<b>protecci\u00f3n\u00a0<\/b>contra el Alzheimer y, en ese caso, perfeccionar un tratamiento contra la enfermedad. Para comprobarlo, introdujeron un gen que reduc\u00eda la actividad de la enzima PDE4B en ratones con Alzheimer. As\u00ed, observaron que los ratones con PDE4B reducida gen\u00e9ticamente ten\u00edan la memoria mucho menos da\u00f1ada que el resto, as\u00ed como un nivel de glucosa m\u00e1s saludable en el cerebro.<\/p>\n<p class=\"paragraph\" data-mrf-recirculation=\"Links inline\">Entonces, \u00bfcu\u00e1les eran los mecanismos implicados en este proceso? Para comprenderlo mejor, los cient\u00edficos observaron qu\u00e9 niveles de expresi\u00f3n de genes y prote\u00ednas ten\u00edan en el cerebro estos ratones. Aquellos que sufr\u00edan de Alzheimer mostraban una mayor\u00a0<b>inflamaci\u00f3n en el cerebro<\/b>, aunque esta era\u00a0<b>menor\u00a0<\/b>en los ratones con la<b>\u00a0PDE4B gen\u00e9ticamente reducida<\/b>. Estos hallazgos pueden abrir una v\u00eda para el desarrollo de nuevos f\u00e1rmacos que traten los s\u00edntomas neurodegenerativos propios del Alzheimer.<\/p>\n<div class=\"inline_2_DSK ad-wrapper ad-desktop\">\n<div class=\"dfpAd ad-inline\">\n<div id=\"infobae\/espana\/nota\/inline_2_DSK\" class=\"infobae\/espana\/nota\/inline_2_DSK arcad\" data-google-query-id=\"CJuftoyIkoUDFbHLKAUdL68ECQ\">La Cl\u00ednica Mayo define la enfermedad de Alzheimer como un\u00a0<b>trastorno cerebral progresivo<\/b>\u00a0que afecta la memoria, el pensamiento y el comportamiento y que se caracteriza por cambios en el cerebro que resultan en la p\u00e9rdida de memoria y habilidades cognitivas. Sus s\u00edntomas suelen desarrollarse lentamente y empeorar con el tiempo, interfiriendo eventualmente con las actividades diarias. Esta enfermedad es la\u00a0<b>forma m\u00e1s com\u00fan de demencia\u00a0<\/b>entre las personas mayores y se manifiesta con problemas de memoria, desorientaci\u00f3n, cambios en el humor y el comportamiento, entre otros s\u00edntomas.<\/div>\n<\/div>\n<\/div>\n<div data-google-query-id=\"CJuftoyIkoUDFbHLKAUdL68ECQ\"><\/div>\n<div data-google-query-id=\"CJuftoyIkoUDFbHLKAUdL68ECQ\">\n<div class=\"headline-wrapper\">\n<h2 class=\"header headline-class-h2\">La presencia del Alzh\u00e9imer en Espa\u00f1a<\/h2>\n<\/div>\n<p class=\"paragraph\" data-mrf-recirculation=\"Links inline\">En\u00a0<b>Espa\u00f1a<\/b>, la enfermedad de Alzheimer afecta aproximadamente a\u00a0<b>800.000 personas<\/b>, seg\u00fan los datos m\u00e1s recientes. Es la forma m\u00e1s com\u00fan de demencia, representando entre el 60% y el 70% de todos los casos de esta condici\u00f3n en el pa\u00eds. La prevalencia de esta enfermedad neurodegenerativa aumenta con la edad, siendo m\u00e1s com\u00fan en personas mayores de 65 a\u00f1os. Sin embargo, tambi\u00e9n puede presentarse en individuos m\u00e1s j\u00f3venes, en lo que se conoce como Alzheimer de inicio temprano.<\/p>\n<p class=\"paragraph\" data-mrf-recirculation=\"Links inline\"><i>Te puede interesar:\u00a0<\/i><a href=\"https:\/\/www.infobae.com\/espana\/2024\/03\/23\/cientificos-espanoles-descubren-el-posible-origen-de-la-ela\/#:~:text=Cient%C3%ADficos%20del%20Centro%20Nacional%20de,esclerosis%20lateral%20amiotr%C3%B3fica%2C%20la%20ELA.\" target=\"_blank\" rel=\"noopener noreferrer\" data-mrf-link=\"https:\/\/www.infobae.com\/espana\/2024\/03\/23\/cientificos-espanoles-descubren-el-posible-origen-de-la-ela\/\"><i>Cient\u00edficos espa\u00f1oles descubren el posible origen de la ELA<\/i><\/a><\/p>\n<p class=\"paragraph\" data-mrf-recirculation=\"Links inline\">La incidencia de la enfermedad de Alzheimer en Espa\u00f1a ha ido\u00a0<b>en aumento<\/b>\u00a0en las \u00faltimas d\u00e9cadas, en parte debido al\u00a0<b>envejecimiento de la poblaci\u00f3n<\/b>. Este crecimiento representa un desaf\u00edo para el sistema de salud y los servicios de atenci\u00f3n a largo plazo, ya que la enfermedad requiere de cuidados especializados y constantes.<\/p>\n<p data-mrf-recirculation=\"Links inline\">(<em>Con informaci\u00f3n de Infobae)<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un ensayo en ratones muestra que la reducci\u00f3n de la enzima PDE4B disminuye la inflamaci\u00f3n del cerebro, propia de este tipo de demencia Un grupo de investigadores de la Universidad de Leeds y la Universidad de Lancaster en el Reino Unido han identificado un nuevo objetivo potencial para el\u00a0tratamiento\u00a0de la enfermedad de\u00a0Alzheimer: la\u00a0PDE4B. La PDE4B [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":84804,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_mi_skip_tracking":false},"categories":[6],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Avance clave en el tratamiento del Alzheimer: la reducci\u00f3n de una enzima del cerebro puede proteger contra la enfermedad - The citizen for the world<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/thecitizenfortheworld.com\/?p=84803\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Avance clave en el tratamiento del Alzheimer: la reducci\u00f3n de una enzima del cerebro puede proteger contra la enfermedad - The citizen for the world\" \/>\n<meta property=\"og:description\" content=\"Un ensayo en ratones muestra que la reducci\u00f3n de la enzima PDE4B disminuye la inflamaci\u00f3n del cerebro, propia de este tipo de demencia Un grupo de investigadores de la Universidad de Leeds y la Universidad de Lancaster en el Reino Unido han identificado un nuevo objetivo potencial para el\u00a0tratamiento\u00a0de la enfermedad de\u00a0Alzheimer: la\u00a0PDE4B. 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